St Louis, MO
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High Profile Cannabis Shop

St Louis

10425 Watson Rd, St. Louis, MO 63127
(314) 353-9922
Closed. Opens at 8:00am (CT)
All hours
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Sun
8:00am
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9:00pm
8:00am
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9:00pm
8:00am
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9:00pm
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9:00pm
8:00am
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10:00pm
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Offered at High Profile St Louis

In-store Shopping

Drop in anytime

In-store Pickup

Reserve online

Budtender Help

Call ahead or come see us

Recreational 21+

Shop with a valid ID

Medical 18+

Shop with a valid Med Card

Cash Payments

Old fashioned green

ATM Onsite

With a small fee

Pay By Bank

Link your bank at checkout online

Free Parking Lot

With plenty of spots

Wheelchair Accessible

Parking and Entrance

Missouri's Premier Recreational Dispensary Is in St. Louis

Missouri legalized recreational cannabis in November 2022 — and High Profile Cannabis has been St. Louis’s premium destination for it since day one. Find us at 10425 Watson Rd in Sunset Hills, right off I-44 on Historic Route 66, with 1,200+ tested and regulated cannabis products across every category. Whether you live in south St. Louis County, you’re passing through on the interstate, or you’re visiting from a state where cannabis is still off the table, this is where the experience starts.

Shop at High Profile and Save

Save big every day at High Profile with competitive prices, discounted bundles, and fresh promos.
Shop All Discounts

Everyday discounts available in-store

20% off

First Time Customers

With High Rollers Rewards signup

15% off

Med Patients - Mon and Tues

With valid Med Card

Veterans - Tuesdays

Thank you for your service

10% off

Industry

Current cannabis industry employees

Student / Faculty

Active students and staff

Veterans

Thank you for your service

Wisdom 60+

All customers age 60+

*Not stackable with other discounts or offers. Applicable in-store only.

Save on Cloud Cover pre-rolls

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Save on featured distillate carts

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Save on Galactic 300mg gummies

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What’s new

Get the scoop on all new and upcoming deals, promotions, and events.
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Earn rewards, unlock personalized promotions and early access. It’s good to be a High Roller.
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About High Profile

How our origin story is shaping our future. Learn about our No Assholes philosophy.
Learn More

Other High Profile Dispensaries in Missouri

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Chesterfield

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Columbia

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Holland

80 State Hwy O, Steele, MO 63877 (573) 255-0342 Shop Now

Pineville

35 Macadoodle Ln, Pineville, MO 64856 (417) 202-0469 Shop Now

St Charles

1416 Harvestowne Industrial Dr, St Charles, MO 63304 (636) 224-6033 Shop Now

St Louis

10425 Watson Rd, St. Louis, MO 63127 (314) 353-9922 Shop Now

St Robert

231 St Robert Blvd, St Robert, MO 65584 (573) 586-4208 Shop Now

West Plains

1391 Mitchell Rd, West Plains, MO 65775 (417) 596-9086 Shop Now
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St Louis

10425 Watson Rd, St. Louis, MO 63127
(314) 353-9922
8am - 9pm Sun - Thurs., 8am - 10pm Fri - Sat.
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Closed. Opens at 8:00am (CT)
10425 Watson Rd, St. Louis, MO 63127
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